Research Journal of Pharmaceutical Dosage Form and Technology

S. J. Daharwal ¹, Rajendra K. Jangade ², Veena Devi Thakur ², Shikha Srivastava ², Bhanu Pratap Sahu ²

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN
2 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.), IN

Abstract

Patient convenience and patient compliance-oriented research in the field of drug delivery has resulted in bringing out potential innovative drug delivery options. Out of which Medicated chewing gum delivery system is convenient, easy to administer - anywhere, anytime - and is pleasantly taste making it patient acceptable. It offers a wide range of advantages that make it an excellent alternative. Various characterization parameters like hardness, drug content, stability and drug release were studied and best formulation was chosen.

Keywords

Chewing Gum, Stability, Innovative.

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S. J. Daharwal ¹, Vaminee Madhukar ¹, Deepak Kumar Biswas ¹, Astha Verma ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (CG), IN

Abstract

The purpose of this study was to evaluate the effect of polymer percentage on the in vitro release profile of Metoclopramide Hydrochloride. Several controlled release matrices of Metoclopramide Hydrochloride with different proportions of hydroxypropylmethylcellulose (viscosity 35-65 cps) and microcrystalline cellulose as water soluble filler were prepared. In this study different percentages of polymers 40, 50 and 60% were used for the development of floating matrix tablet of metoclopramide hydrochloride. The results showed that with increase in polymer concentration release of drug from matrices decreases and swelling of matrices increases. When an appropriate blend of hydroxypropylmethylcellulose (50%) and microcrystalline cellulose was used, the drug release became more uniform and its release fluctuations were diminished. The results with these polymer blends showed that it is possible to reduce the total amounts of polymer in each formulation. According to kinetic analysis data, drug release from these matrix tablets did not follow Fick's law of diffusion and the results were in agreement with the earlier reports.

Keywords

Metoclopramide Hydrochloride, Matrices, Hydroxypropylmethylcellulose, Microcrystalline Cellulose.

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Juned Khan ¹, Ajazuddin ¹, S. J. Daharwal ², Deependra Singh ²

Affiliations
1 Rungta College of Pharmaceutical Sciences and Research, Bhilai (CG) 490024, IN
2 Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010, IN

Abstract

Many people suffer from dandruff problem. The dandruff occurs generally on the hair covered skin, specially the scalp skin. It is known to be controlled by antifungal agents. The present study was carried out to asses the effect of three minutes contact period on the efficacy of antidandruff shampoos. 1% Ketoconazole, 1% Piroctone olamine and 1% Zinc pyrithione were individually formulated in a shampoo base and were used for the study. Three groups of ten patients each with severe dandruff were taken such that each group was treated with only one of the antidandruff agent. Scoring of the dandruff was done on a 0 to 10 scale for each of the three regions of scalp at first and fourteenth day respectively. All the three antidandruff shampoo treated groups improved significantly with a contact period of three minutes rather than no contact period.

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Rajendra Jangde ¹, Rahul Singhour ², S. J. Daharwal ¹

Affiliations
1 University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur (C.G.) 492010, IN
2 Aristo Pharmaceutical Mandideep, Bhopal (M.P.), IN

Abstract

Proper formulation is an important aspect of any dosage form design. FTIR and Differential scanning calorimeter were used to evaluate the compatibility of Gatifloxacin and selected Excipients used in the development of suspensions formulation. In the first phase of Differential scanning calorimeter was used in the any interaction. In the next phase, excipients defined as prototype formula were tested for their compatibility with Gatifloxacin. Based on the results, methyl paraben and polyvinyl pyrrolidone were found show interaction with Gatifloxacin. Results of Differential scanning calorimeter and FT-IR demonstrated incompatibility between Gatifloxacin and MethylParaben. All the excipients defined in the prototype formula were found to be compatible with Gatifloxacin. Using the Excipients that were found to be compatible with Gatifloxacin. FT-IR and Differential scanning calorimetry was used to investigate the physicochemical compatibility between Gatifloxacin and various used in suspension manufacturing. The Gatifloxacin found to be compatatible with polyvinyl alcohol and acacia. Although interactions of Gatifloxacin with methyl paraben, polyvinyl pyrrolidone were observed. It cannot be conclusive stasted that interactions incompatibility will occur during storage at room temperature.

Keywords

Gatifloxacin, FTIR, Differential Scanning Calorimetry, Pharmaceutical Excipents, Preformulation Compatibility.

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